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Dr. Ramesh Munshimappa mentions Onychomycosis remains one of the most common nail disorders encountered in clinical practice, often requiring a tailored treatment approach based on disease severity and patient factors. While topical therapies offer a safe and convenient option for mild to moderate cases, oral antifungal agents continue to provide higher cure rates, particularly in extensive nail involvement. Understanding the advantages, limitations, and appropriate indications for each modality is crucial for optimizing treatment outcomes. As dermatologists, selecting the right therapy through an individualized, patient-centric approach can significantly improve both clinical success and patient satisfaction