This is an excerpt from a podcast featuring Dr. Shashidhar, who discusses the use of nutritional supplements to manage acne. Dr. Shashidhar identifies several nutrients with definitive evidence of benefit, including zinc, omega fatty acids, vitamin D, and probiotics, detailing the mechanisms and recommended dosages for each. Specifically, zinc, omega-3s, and vitamin D are praised for their anti-inflammatory actions, while probiotics are noted for improving the gut–skin axis and reducing systemic inflammation. Conversely, the podcast warns that supplements like whey protein and vitamin B12 may potentially exacerbate acne. The presentation distinguishes between supplements with clear benefits and those, such as vitamin A and selenium, that have mixed evidence regarding their effectiveness for skin health.