Psoriasis is strongly associated with obesity, which can reduce the efficacy of biologic and conventional therapies, increase side effects, and affect drug survival. An expert panel reviewed available evidence and developed consensus recommendations to optimize care for this population. Weight control is an essential component of psoriasis management, alongside expanding therapeutic options.
Psoriatic disease is linked to an increased risk of all-cause mortality compared to individuals without the condition, even after adjusting for comorbidities. The risk appears higher in psoriasis but not in psoriatic arthritis, with a possible increase among those receiving biologic therapy.
Greater consumption of vitamins E, K1, C, B2, and D from whole foods was associated with reduced odds of atopic dermatitis in young Chinese adults in Singapore and Malaysia. The protective effect of vitamin C remained after adjusting for smoking and was amplified by higher fruit intake.
Daily emollient application starting before 9 weeks of age lowered the 24-month cumulative incidence of atopic dermatitis in a representative infant population. The benefit was greater in those not at high risk and was influenced by dog exposure in the home. No increase in cutaneous adverse events was observed.
Facial melasma and nuclear cataracts share ultraviolet (UV) exposure as a common risk factor, but their association remains underexplored. Individuals with melasma have been shown to have a 2.6-fold higher risk of developing nuclear cataracts.
Vitiligo is a chronic autoimmune skin disorder prone to recurrence after treatment. This study identified key inflammatory cytokines—IFN-γ, CXCL9, CXCL10, CXCL11, and IL-6—as potential plasma biomarkers for predicting vitiligo relapse. IFN-γ was found as an independent predictor, supporting its clinical utility.
Reduced levels of protein-bound ceramides (POS) in the skin at 6 weeks of age are associated with an increased risk of developing atopic dermatitis (AD) by age 1. The strongest predictive lipid was PO30:0-C20S, especially for non-sensitized AD. These findings suggest that early lipid biomarkers may help in predicting and potentially preventing AD
Metabolomic profiling of sebum in acne patients offers a unique approach to identify precision treatment targets beyond isotretinoin. This method characterizes lipidomic alterations, inflammatory mediators, and microbial metabolites, revealing distinct metabolic signatures linked to acne severity.
A trial compared fractional CO2 laser with topical tioconazole to Q-switched Nd:YAG laser for onychomycosis. The fractional CO2 laser group showed significantly greater OSI score improvement, while both groups improved in DLQI and satisfaction scores.
A study comparing clindamycin 1% gel alone vs. its combination with benzoyl peroxide 2.5% cream found the combination therapy significantly more effective in reducing lesion count and improving global assessment scores.
