Roflumilast foam, 0.3%, significantly improved scalp and body psoriasis and reduced itch within weeks, with low adverse event rates. It offers an effective, well-tolerated topical monotherapy option for patients aged 12 and older.
This large multicentre study (N=107) evaluated an autologous skin cell suspension (ASCS) prepared by a cell harvesting device for treating stable vitiligo. Lesions were laser-ablated and treated with ASCS followed by home phototherapy. By week 24, all lesions improved—67% showed >50% repigmentation, 42% achieved ≥80%, and 8% achieved complete repigmentation. Significant improvements in quality-of-life and patient satisfaction were reported. The device simplifies melanocyte transplantation, offering an effective, accessible approach for repigmentation in stable vitiligo.
This case–control study of 100 acne patients and 100 controls found that individuals with acne had significantly higher neuroticism and lower extraversion scores. They also showed reduced self-esteem compared to controls, highlighting the psychological impact of acne vulgaris.
This study found that COâ‚‚ fractional laser and microneedling pretreatment significantly enhanced the efficacy of ALA-PDT in moderate to severe acne. The COâ‚‚ laser group showed the highest effectiveness (88%), better outcomes than microneedling (62%) and control (36%), with no serious side effects or recurrence after 12 weeks.
This study found that the vitamin D receptor (VDR)-FokI CC genotype has a protective effect against acne and seborrhea in women with PCOS. It also showed that VDR gene variants, particularly the VDR-TaqI dominant genotype, were associated with reduced oxidative stress and may influence the role of vitamin D in PCOS-related skin manifestations.
This case-control study found no significant difference in ADHD prevalence or scores between individuals with and without acne vulgaris. ADHD frequency was slightly higher in younger patients, women, and those with severe acne, but not statistically significant.
A 16-week Mediterranean diet plus algae-derived omega-3 supplementation significantly increased EPA/DHA levels and reduced acne severity in patients. Most showed clinical and quality-of-life improvements without adverse effects.
A recent study has highlighted a significant association between early-onset atopic dermatitis and an increased risk of pediatric uveitis. Children with severe AD showed the highest risk, and the link persisted even after excluding autoimmune conditions or dupilumab use.
Androgenetic alopecia (AGA) is increasingly recognized in pediatric populations, though data remain limited. In a multicenter review of patients <18 years of age, mean onset was at 12.9 years, with prepubertal onset in some cases. Obesity and family history emerged as potential risk factors.
A study in psoriasis patients starting their first biologic found that lower body mass index (BMI), fewer comorbidities, and family history of psoriasis predicted super-response, while higher BMI, non-alcoholic fatty liver disease, and more severe disease predicted biologic refractoriness. Super-responders had better treatment persistence, whereas refractory patients showed poorer persistence.
